- The Association of Central Obesity with Type 2 Diabetes among Koreans according to the Serum Gamma-Glutamyltransferase Level: Korean Genome and Epidemiology Study.
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Ji Yeon Shin, Jun Hyun Hwang, Jin Young Jeong, Sung Hi Kim, Jai Dong Moon, Sang Chul Roh, Young Wook Kim, Yangho Kim, Jong Han Leem, Young Su Ju, Young Seoub Hong, Eun Hee Ha, Yong Hwan Lee, Duk Hee Lee, Dong Hyun Kim
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J Prev Med Public Health. 2009;42(6):386-391.
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DOI: https://doi.org/10.3961/jpmph.2009.42.6.386
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 Abstract
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- OBJECTIVES
This cross-sectional study was performed to examine if the serum gamma-glutamyltransferase (GGT) level that is within its normal range is associated with the risk of type 2 diabetes and if the association between the waist hip ratio (WHR) and type 2 diabetes is different depending on the serum GGT levels. METHODS: The study subjects were 23,436 persons aged 40 years or older and who participated in regular health check-ups at 11 hospitals (males: 5,821, females: 17,615). The gender-specific quintiles of the serum GGT and WHR were used to examine the associations with type 2 diabetes. RESULTS: The serum GGT levels within their normal range were positively associated with type 2 diabetes only in women. The adjusted odds ratios (ORs) were 1.0, 1.0, 1.4, 2.1, and 2.5 according to the quintiles of the serum GGT (p(trend)<0.01). The WHR was more strongly associated with the prevalence of diabetes among the women with a high-normal serum GGT level as compared with those with a low-normal serum GGT level (p for interaction=0.02). For example, the adjusted ORs for women with a low normal serum GGT level were 1.0, 1.2, 1.5, 2.2, and 2.4 according to the quintiles of the WHR, while those figures were 1.0, 2.4, 3.6, 5.0, and 8.3 among the women with a high normal serum GGT level. However, in men, the serum GGT was very weakly associated with type 2 diabetes and the association between the WHR and type 2 diabetes was not different depending on the serum GGT level. CONCLUSIONS: Serum GGT within its normal range was positively associated with type 2 diabetes, and central obesity was more strongly associated with the prevalence of type 2 diabetes when the serum GGT level was high-normal. However, these associations were observed only in women, which is different from the previous findings. The stronger relation between central obesity and type 2 diabetes among women with a high-normal serum GGT level can be useful for selecting a group that is at high risk for type 2 diabetes irregardless of whatever the underlying mechanism is.
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Citations
Citations to this article as recorded by  - Serum gamma-glutamyl transferase and risk of type 2 diabetes in the general Korean population: a Mendelian randomization study
Youn Sue Lee, Yoonsu Cho, Stephen Burgess, George Davey Smith, Caroline L. Relton, So-Youn Shin, Min-Jeong Shin
Human Molecular Genetics.2016; 25(17): 3877. CrossRef - Different associations between obesity and impaired fasting glucose depending on serum gamma-glutamyltransferase levels within normal range: a cross-sectional study
Nam Soo Hong, Jeong-Gook Kim, Yu-Mi Lee, Hyun-Woo Kim, Sin Kam, Keon-Yeop Kim, Ki-Su Kim, Duk-Hee Lee
BMC Endocrine Disorders.2014;[Epub] CrossRef - Endobiogeny: A Global Approach to Systems Biology (Part 1 of 2)
Jean-Claude, Lapraz, Kamyar M. Hedayat
Global Advances in Health and Medicine.2013; 2(1): 64. CrossRef
- A study on the factors afecting the subjective symptoms of VDT syndrome.
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Jai Dong Moon, Min Chul Lee, Byong Woo Kim
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Korean J Prev Med. 1991;24(3):373-389.
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- In order to develop the measuring tool of VDT syndrome and investigate the variables affecting the development of VDT syndrome, a questionnaire study accompanied with the evaluation of working environment was performed with 138 VDT users from six public organs in Kwangju area. The result were summarized as follows: 1. As a result of analysis with data collected by newly developed questionnaire, VDT syndrome included five factors named as eye-related component, psychological component, general body component, musculoskeletal component, and skin-related component and the estimates of the internal consistency of five factors were 0.877, 0.820, 0.796, 0.791, 0.593 respectively. 2. Variables affecting the level of eye-related symptoms were the type of main job using VDT, the total time of VDT operation per day, and the use of external filter on CRT. 3. The level of eye-related symptoms in the group using external filter was higher significantly than that in the group not using filter. 4. The past history of severe illness affected the level of psychological symptoms significantly. 5. Variables affecting the level of general body symptoms were job satisfaction and income satisfaction. 6. Variables affecting the level of musculoskeletal symptoms were the type of main job using VDT, whether majored in EDPS, the level of typewriting, job satisfaction, and the total time of VDT, operation per day. 7. Age and the use of external filter were significantly related to the level of skin-related symptoms. 7. Age and the use of external filter were significantly related to the level of skin-related symptoms.
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Summary
- Effect of Mercury and Lead on the Biochemical Oxygen Demand (BOD).
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Jai Dong Moon
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Korean J Prev Med. 1984;17(1):217-222.
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- In order to estimate interfering effects of mercury and lead on biochemical oxygen demand (BOD), BOD in 18 effluent samples were measured under three different concentrations of mercury and lead. The results obtained were as follows: 1. Biochemical oxygen demand(BOD) was decreased under the presence of mercury and lead, with parallel correlation of mercury concentration. 2. High correlations were noted between original BOD concentration and decreasing amount of BOD when concentrations of mercury or lead were increased. 3. When the lead concentration was high, the close correlation was observed between total organic carbon(TOC) and decreasing amount of BOD. 4. There was a negative correlation between TOC/BOD ratio and decreasing amount of BOD when the mercury concentrations were high.
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Summary
- An Epidemiological Study on the Decompression Sickness in an Underwater Work.
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Jai Dong Moon, Ill Sup Chin, Yang Ok Kim
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Korean J Prev Med. 1984;17(1):211-216.
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- Forty one male workers employed in an underwater construction field were surveyed in the viewpoints of epidemiological analysis of decompression sickness (caisson's disease). Nineteen out of the entire forty one workers have been, or had been suffering from decompression sickness (as 46.3% of incidence rate) after decompression. The results obtained were as follows: 1. There was a significant relation between duration of work and incidence of disease. 2. Type II (severe type) comprised majority of cases (16 cases, 84.2%) despite any significant correlations were not present between severity types and recompression times. 3. Most frequently cited symptoms were lower limb pain (89.5%), upper limb pain (79.0%), pruritus (68.4%) and so on, however, 10% of patients complained of neurological symptoms. 4. There were not any significant correlations between incidence and worker's age or relative body weight.
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